WHAT IS KEYTROPIN?
KeyTropin? contains a highly advanced, patent pending polypeptide called HTA-5? that may stimulate the body?s own production of Growth Hormone.


INTRODUCTION
Many scientists now regard aging as both treatable and reversible. At the core of aging is the body's progressive inability at self-repair and marked decrease in hormone levels. The application of this theory, and the unprecedented growing popularity of hormonal supplementation, testifies to the success of hormone replacement therapy as an effective means of countering the aging process, while restoring the body?s ability to self-repair.


THEORIES OF AGING
The precise reason Growth Hormone levels decrease with advancing age is unknown. However, there are a number of theories that begin to explain this depression within the context of an organism?s natural aging process. The theories are as follows:

Oxidative Stress Theory asserts that the body?s absorption of oxygen is intricately related to the aging process. The more food a person or animal consumes, the more oxygen the body needs to break it down into energy, and the more rapidly the animal ages due to the creation of free radicals that impair cell function.

The Genetic Theory of Aging asserts that as genetic damage accumulates simply as a consequence of living (i.e. via ongoing cell repair and division); the body?s overall efficiency decreases, with aging as a consequence.

The Theory of Somatopause (or Cellular Senescence) asserts that cells are pre-programmed to either die after a finite number of divisions or simply go dormant. As the cells lapse into this phase of their cycle, the efficiency of the organism to maintain its vital functions decreases, until ultimately the organism itself dies.

The Hormonal Theory of Aging asserts that aging is linked to a decline in the body?s secretion of a variety of hormones without losing the ability to respond to these hormones. This is the principle basis for hormone replacement therapy with GH.

Comment: Cellular senescence may be caused by the decreasing length of protective telomeres that are positioned like protective caps at the ends of chromosomal DNA. A part of the telomere cap is lost with each successive cell division, eventually reaching a critical length at which time cell division stops and the cell ages and dies. Preservation of these caps preserves cell viability.


WHAT IS GROWTH HORMONE?
Mounting science and clinical evidence have documented the usefulness of Growth Hormone (GH) as an anti-aging tool and have ensured the continued relevance of GH in an ongoing exploration of anti-aging medicine. Central to GH?s value as an anti-aging tool is its ability to promote cell regeneration, stimulate tissue repair and energize the immune system. Since virtually all the complications related to aging appear to stem from the body?s progressive inability to repair its cells as it loses them, GH appears to be center stage in the anti-aging arena.

Growth Hormone is a 191 amino acid protein chain that is synthesized and secreted by the pituitary gland found at the base of the brain. GH enters the bloodstream in pulses, predominantly at night, and is quickly metabolized by the liver into insulin-like growth factors IGF-1 and IGF-2. The natural decrease of GH secretion with age starts in the mid-twenties and continues as we grow older. By the age of 60, GH levels are typically 80-85% of their levels at the age of 25, sometimes even higher

GROWTH HORMONE BENEFITS
People who have used injectable GH have reported an overall improvement in their general well-being and vitality, with the following specific findings:

? Stronger bones
? Enhanced immune system
? Accelerated wound healing / tissue regeneration
? Decrease in total cholesterol
? Increase in muscle mass without exercise
? Loss of body fat without exercise
? Weight loss
? Improved blood pressure
? Younger, more durable skin with fewer wrinkles
? Increased energy
? Enhanced sexual performance and libido
? Increased cardiac output
? Enhanced exercise performance
? Improved mood
? Improved memory
? Improved sleep pattern
? Organ regeneration
? Regrowth of lost hair


INSULIN-LIKE GROWTH FACTORS IGF-1 AND IGF-2
During the day, GH is released into the bloodstream in small pulsating bursts, peaking during deep sleep. . Since the longevity of GH in the bloodstream is very short after its secretion, accurately measuring GH levels directly requires that blood be drawn in study subjects immediately after using a suspected GH-stimulating substance. This makes testing for elevations of the actual GH hormone difficult and often impractical. Because Insulin-like Growth Factor 1 (IGF-1).

IGF-1 is produced by the liver in response to circulating GH and remains relatively constant throughout the day in contrast to GH. As such, IGF-1 levels have traditionally been the standard means to evaluate how much GH the pituitary is releasing, especially when looking for a change over time. Consequently, in the KeyTropin studies, IGF-1 concentrations were determined by collecting participant blood samples at the beginning of the studies and at their conclusion.

Although studies in the past suggest that elevated GH levels in subjects over time generally has resulted in elevated IGF-1 levels, many conditions and substances other than GH can produce elevated IGF-1 levels. Additionally, in other studies where GH and IGF-1 levels were measured immediately after using GH-stimulating substances, subjects demonstrated no increase in IGF-1 levels from baseline readings, as GH levels were rising. This makes using IGF-1 as a marker for GH a highly questionable issue that requires further research. Accordingly, the information provided in the KeyTropin studies about the changes subjects experienced in IGF-1 levels is intended only to suggest that the subjects experienced elevations in GH levels when viewed in tandem with other subjective and objective study outcomes.

Using measurements of hormone levels as an indicator of the real world benefits associated with the use of any hormone-related product, as in this case a GH secretagogue, is often not a practical, realistic or meaningful method for a multitude of physiological and biochemical reasons. For example, although certain testosterone-stimulating prohormones, being marketed as dietary supplements, have demonstrated elevations in circulating testosterone, the data has not demonstrated the subjects have experienced any significant real world testosterone-related benefits. What value, then, do these products have to consumers? The ultimate goal is to produce real world improvements in life quality, which can be measured objectively (lower cholesterol, improved blood pressure, stronger bones, reduced body fat, increased body leanness) and subjectively (heightened libido, increased energy, more restful and improved sleep patterns, improved memory and mood).
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Comment: IGF-1 works directly with GH to promote growth and regulate metabolism. IGF-2 maintains the health of nerve tissue and works with GH to stimulate bone marrow and bone growth. The goal of GH replacement therapy by injection for individuals over 50 is to raise IGF-1 levels within the range of healthy young adults, which is between 500 to 1500 U/
THE TRUTH BEHIND GROWTH HORMONE CONTAINING ORAL SPRAYS
The inclusion of GH in an oral spray for the purpose of increasing GH levels in the body raises serious questions of legitimacy.

GH is a prescription drug and legally cannot be included in a dietary supplement, no matter how minute the quantity.

GH taken via an oral spray cannot be absorbed through the oral mucosa because of its large size of 191 amino acids. The upper threshold of trans-mucosal absorption for peptides is around 60 amino acids. Many marketers of products that purport to contain GH claim to have a "delivery system" that allows for the transport of GH via an oral spray, yet there exists no science to support their claims. If a legitimate technology existed for the purpose of transporting GH into the body via an oral spray, the drug companies holding GH patents would have implemented this technology to offer the public a means of GH replacement therapy that did not require injections.

Oral absorption of HTA-5 is based on the peptide?s small size and its ability to be readily absorbed through the oral mucosa. The developers of HTA-5 chose to assist the transmucosal absorption of HTA-5 by including a non-proprietary and relatively small sugar/protein transport molecule called a glycosaminoglycan, or GAG molecule, into the formulation. This transport molecule increases the transmucosal absorption of HTA-5 and also helps to stabilize HTA-5 in the formulation. HTA-5 was attached to GAG molecules in all clinical trials performed to date.

In addition to GH?s large size as a prohibitive factor for an oral spray formulation, it should also be noted that GH in liquid form is extremely unstable. Consequently, although there may be some degree of concentration of GH placed in solution at the time of manufacture, the GH will be rapidly destroyed and final levels of GH by the time the product gets into the hands of the end consumer will be very low, if existent at all. At this time, there is no sure fire technology available to stabilize GH in solution, especially in the type of solutions being used in these products. The only means of maintaining GH in solution to date has been to reconstitute GH in a solution that contains a scientifically precise environment (bacteriostatic water) immediately before injection. The reconstituted GH must be refrigerated and then only remains stable for a matter of days.

The amount of GH alleged to be contained in most GH-containing oral sprays is too insignificant to produce any notable GH-related benefit, even if the GH were viably active and could be delivered to the bloodstream. The amount of GH claimed to be contained in a typical serving of GH-containing oral sprays represents less than 001% of the amount of GH found in a typical injection taken for GH replacement therapy.

When approached by someone trying to sell you a product that purports to contain GH, simply say to that person, "Show me the science behind your product."


KEYTROPIN VERSUS GROWTH HORMONE INJECTIONS
KeyTropin with HTA-5 is ideal for those individuals whose objective is to benefit from an increase in their body?s own release of GH without the risk of interfering with their body's own production and release of GH. In particular:

KeyTropin use will not suppress the body?s natural cyclical release of GH, as is commonly the case with GH injections. Consequently, you may start and stop the use of KeyTropin without risk.

KeyTropin users can comfortably use HTA-5 in the absence of physician supervision because HTA-5 does not expose the body to the pharmacologic concentrations of GH commonly used with GH injections.


MAXIMIZING YOUR GROWTH HORMONE LEVELS
The decrease in GH synthesis and secretion during a lifetime is a natural phenomenon consistent with the aging process. The following is a list of simple and effective techniques that increase GH secretion naturally and with varying degrees of effort.

Exercise and strength training. Weight training that uses leg, chest and back muscles has been shown to be the best natural stimulant for invigorating the body and stimulating GH secretion.

Raising blood sugar levels decreases GH secretion. Avoid eating before bedtime and minimize your intake of simple sugars found in soda, fruit juice, candy and other snack products.

Increase your dietary protein intake from poultry, fish, dairy products, and soy and meat products. Protein intake is fundamental to tissue regeneration


KEYTROPIN PRODUCTS
KeyTropin is available as an oral spray.

KeyTropin Oral Spray
The oral spray provides HTA-5? in smaller doses more than once daily.


LABEL INFORMATION

KeyTropin Oral Spray
Ingredients: HTA-5? polypeptide containing the following amino acids: Leucine, Proline, Lysine, Glutamine, Aspartic Acid, Metionin, Alanine